Cell subtype · L1S

DC.cDC2

9,277 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

Read trait, study and gene evidence reports for this population →

Explore this population in Cell Browser →

Marker genes

CD1C, FCER1A, CLEC10A, CD1E, IRF4

Annotation genes

CD1C, CLEC10A, IRF4

Annotation rationales

Conventional type-2 dendritic cells are CD1C-positive antigen-presenting cells with broad capacity to sample extracellular antigens.

Functional implications

They prime and polarize CD4 T-cell responses and coordinate immunity to diverse extracellular pathogens and tissue signals.

More specific populations

DC.cDC2.adhesion_signaling
DC.cDC2.antiviral
DC.cDC2.lipid_metabolic
DC.cDC2.migratory
DC.cDC2.monocyte_like
DC.cDC2.pro_inflammatory
DC.cDC2.proliferative
DC.cDC2.tolerogenic_regulatory

Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.