Cell state · L2
DC.cDC2.pro_inflammatory
915 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BCL2A1, BIRC3, CCR7, CXCL2, CXCL3, CXCL8, G0S2, ICAM1, IER3, IL1A, IL1B, IL1R2, MIR155HG, NFKBIA, PLAUR, ZC3H12A
Annotation genes
CCR7, CXCL2, CXCL8, IL1B
Annotation rationales
IL1B and CXCL chemokines (CXCL8/CXCL2/3) define potent neutrophilic recruitment; CCR7 denotes LN-bound maturation. NFKBIA/ZC3H12A provide post-transcriptional brakes to avoid runaway signaling.
Functional implications
Drives acute neutrophilic inflammation at the periphery and then migrates to LNs to prime Th17/Th1 pathways, ensuring coordinated systemic and local responses.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.