Cell state · L2
DC.cDC2.lipid_metabolic
209 cells in the full atlas (not the displayed sample).
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Marker genes
APOC1, FABP3, FABP4, FABP5, PPARG, TAGLN
Annotation genes
APOC1, FABP4, PPARG
Annotation rationales
PPARG and FABP4/5 tune lipid uptake and nuclear signaling that rewires antigen presentation and cytokine bias. APOC1 indicates lipoprotein handling linked to tolerance vs inflammation decisions in adipose/liver.
Functional implications
Integrates lipid cues to direct Th2/Treg skewing or restrain Th1/Th17 in metabolically active tissues; buffers lipotoxicity while maintaining APC competence.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.