Cell state · L2
DC.cDC2.adhesion_signaling
1,181 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
C12orf75, CCND3, ENHO, FBLN2, ICAM3, ITGB7, ITM2C, NREP, PLD4, PPP1R14A, RIPOR2, SELL, SIGLEC6, SYTL1, TBC1D10C, UNC119, UPK3A, VIPR1
Annotation genes
ICAM3, ITGB7, SELL, SIGLEC6
Annotation rationales
SELL/ITGB7/ICAM3 optimize lymphoid homing and T-cell synapse formation; SIGLEC6 confers ligand-dependent inhibitory tuning to curb over-stimulation. Cytoskeletal/vesicle regulators (RIPOR2/SYTL1) support motility and cargo delivery.
Functional implications
Positions cDC2 in portals of T-cell traffic (Peyer’s patches/LNs), enabling efficient CD4⁺ priming while using SIGLEC6-mediated braking to avert excessive cytokine storms.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.