Cell state · L2
DC.cDC2.tolerogenic_regulatory
1,650 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ARL4A, ATF3, CXCL16, DNAJB1, FCER1A, FCGR2B, HSPA1A, HSPA1B, NR4A1, NR4A2, PAPSS2, RGS2, SGK1, VSIG4, ZNF331
Annotation genes
FCER1A, FCGR2B, NR4A1, VSIG4
Annotation rationales
FCGR2B and VSIG4 deliver inhibitory input at Fc/complement axes, while NR4A1/NR4A2/ATF3 impose a transcriptional tolerance state; FCER1A enables controlled IgE-mediated antigen acquisition without full activation.
Functional implications
Induces or maintains peripheral tolerance and Treg support, crucial in steady-state tissues and during resolution after infection or allergy.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.