Cell subtype · L1S
T.CD4_naive
75,723 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
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Marker genes
CCR7, SELL, TCF7, LEF1, MAL
Annotation genes
CCR7, TCF7, LEF1
Annotation rationales
Naïve CD4 T cells are mature antigen-inexperienced helper-lineage cells with lymph-node homing and a quiescent, stem-like transcriptional program.
Functional implications
They maintain repertoire diversity and differentiate into specialized helper or regulatory lineages after appropriate antigen and co-stimulatory signals.
More specific populations
- T.CD4_naive.activated_stress
- T.CD4_naive.gut_prone
- T.CD4_naive.homeostatic
- T.CD4_naive.mature
- T.CD4_naive.mature_mitoprot
- T.CD4_naive.neddylation
- T.CD4_naive.neddylation_mitoprot
- T.CD4_naive.proteostasis
- T.CD4_naive.proteostasis_mitoprot
- T.CD4_naive.purinergic
- T.CD4_naive.resist_bystander
- T.CD4_naive.survival
- T.CD4_naive.survival_mitoprot
- T.CD4_naive.survival_neddylation
- T.CD4_naive.Treg_like
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.