Cell state · L2
T.CD4_naive.neddylation_mitoprot
5,669 cells in the full atlas (not the displayed sample).
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Marker genes
HSPE1, UBE2F
Annotation genes
HSPE1, UBE2F
Annotation rationales
Coupling NEDDylation (UBE2F) with mitochondrial chaperoning (HSPE1) balances receptor turnover and organelle proteostasis, guarding against chronic low-grade stimulation.
Functional implications
Maintain quiescence under tonic cytokines while preserving mitochondrial fitness for rapid response.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.