Cell state · L2
T.CD4_naive.activated_stress
798 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ATF3, CSRNP1, RGS1, TNFAIP3, YPEL5
Annotation genes
ATF3, CSRNP1, RGS1, TNFAIP3
Annotation rationales
ATF3/CSRNP1 indicate immediate-early activation and stress buffering; RGS1 dampens chemokine receptor signaling after stimulation; TNFAIP3 (A20) reins in NF-κB. The quartet flags naïve cells recently triggered by antigen or cytokines, resetting thresholds but retaining naïve identity.
Functional implications
Temporarily desensitized naïve cells that recalibrate chemokine responsiveness and NF-κB amplitude, preventing spurious activation while they return to full priming competence.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.