Cell state · L2
T.CD4_naive.neddylation
5,722 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
UBE2F
Annotation genes
UBE2F
Annotation rationales
UBE2F (NEDD8 E2) supports cullin-RING ligase activity, controlling turnover of receptors/adaptors and sharpening activation thresholds without overt activation.
Functional implications
Enforce high activation thresholds by targeted degradation of signaling components, preventing noise-driven priming.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.