Cell subtype · L1S
T.CD4_cytotoxic
5,562 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
NKG7, CCL5, GZMB, PRF1, CTSW
Annotation genes
GZMB, PRF1, CCL5
Annotation rationales
Cytotoxic CD4 T cells are antigen-experienced CD4 lymphocytes that have acquired granule-mediated killing machinery.
Functional implications
They can eliminate infected, senescent or malignant MHC-II-presenting targets while retaining helper and cytokine functions.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.