Cell state · L2
T.CD4_cytotoxic.precursor
710 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AQP3, BEX2, CD27, CD28, CXCR3, GPR183, GZMK, IL7R, LDHB, LEF1, LTB, MYC, TCF7
Annotation genes
CD27, CXCR3, GZMK, IL7R, TCF7
Annotation rationales
CD27/IL7R/TCF7 preserve a stem-like memory scaffold and cytokine-driven survival; CXCR3 biases trafficking to CXCL9/10 inflamed endothelium; GZMK marks early cytotoxic competence without terminal ZEB2/KLRG1 programs. The set (CD27, IL7R, TCF7, CXCR3, GZMK) is a poised pre-CTL blueprint.
Functional implications
Maintain a migratory reservoir that expands quickly on recall and matures into high-output CD4 CTLs in Th1-inflamed tissues; bridges memory and effector compartments.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.