Cell state · L2
T.CD4_cytotoxic.baseline
488 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
GNLY, GZMA, GZMH, KLRG1
Annotation genes
GNLY, GZMA, GZMH, KLRG1
Annotation rationales
GNLY with GZMA/GZMH supports perforin-independent cytolysis (granzyme-mediated, inflammatory) and pathogen control; KLRG1 indicates late-effector imprint and reduced proliferative capacity but sustained killing competence. No extra NK-receptor/chemokine skew → “reference” CD4 CTL phenotype.
Functional implications
Execute standard lysis and Th1-biased antimicrobial control while patrolling and responding broadly to diverse antigenic contexts; good for clearance without heavy tissue anchoring.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.