Cell state · L2
T.CD4_cytotoxic.activated
947 cells in the full atlas (not the displayed sample).
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Marker genes
BHLHE40, CREM, CXCR4, DNAJB6, ENC1, METRNL, PIK3R1, PPP1R16B, SELENOK, SKIL, SYTL3, TNFAIP3
Annotation genes
BHLHE40, CREM, CXCR4, TNFAIP3
Annotation rationales
BHLHE40 and CREM coordinate an immediate-early effector transcriptional burst while shaping cytokine polarity (promote IFN-γ, restrain IL-10) and limiting exhaustion programs; CXCR4 drives retention in CXCL12⁺ niches (LN paracortex, bone marrow) that support serial TCR engagement and survival; TNFAIP3 (A20) imposes NF-κB negative feedback to curb over-activation. Vesicle/trafficking support (SELENOK, SYTL3) fits granule delivery without pushing to terminal fate—consistent with a controlled, re-stimulable CTL.
Functional implications
Rapid “hit-and-hold” cytotoxic/helper output in CXCL12⁺ stromal hubs; quick IFN-γ/TNF pulses and chemokine production to recruit partners, then self-limiting via A20 to avoid exhaustion and preserve recall capacity.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.