Cell state · L2
T.CD4_cytotoxic.terminal_effector
2,298 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ACTR3, CAP1, CASP1, CTSC, CTSW, CX3CR1, GBP5, GIMAP4, PLEK, TBX21, TPM4, WDR1, ZNF683
Annotation genes
CTSW, CX3CR1, TBX21, ZNF683
Annotation rationales
TBX21 (T-bet) and ZNF683 (Hobit) enforce terminal cytotoxic fate and tissue patrol; CX3CR1 enables vasculature-hugging motility and rapid redeployment; CTSW strengthens granule-mediated cytolysis; GBP5/CASP1 in the broader set hints at inflammasome-adjacent antimicrobial tone.
Functional implications
Patrol vasculature and inflamed parenchyma as fully differentiated killers with sustained motility and durable cytotoxic output, ideal for chronic infection control and tumor edge surveillance.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.