Cell subtype · L1S
DC.cDC1
809 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CLEC9A, XCR1, BATF3, CADM1, IRF8
Annotation genes
CLEC9A, XCR1, BATF3
Annotation rationales
Conventional type-1 dendritic cells are BATF3-dependent antigen-presenting cells specialized for sensing material from damaged cells and cross-presenting it on MHC class I.
Functional implications
They prime cytotoxic CD8 T-cell and type-1 immune responses, making them central to antiviral and antitumour immunity.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.