Cell state · L2
DC.cDC1.cross_presenting
167 cells in the full atlas (not the displayed sample).
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Marker genes
CADM1, CCND1, DNASE1L3, FKBP1B, FUCA1, IDO1, MPEG1, NAAA, SDC2, XCR1
Annotation genes
CADM1, DNASE1L3, IDO1, XCR1
Annotation rationales
Reinforced XCR1/CADM1 confirms specialized cDC1 identity; DNASE1L3 limits extracellular DNA-driven autoimmunity during uptake, and IDO1 enforces context-dependent tolerance in high-antigen environments. Lysosomal/ER modules (MPEG1/NAAA) support antigen routing to MHC-I.
Functional implications
Performs efficient cross-presentation of exogenous antigens to CD8⁺ T cells while using IDO1 to calibrate effector magnitude. Critical for antiviral and antitumor priming and for dampening self-reactivity during sterile cell death.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.