Cell state · L2
DC.cDC1.baseline
135 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BATF3, CADM1, CLEC9A, DNASE1L3, IDO1, IRF8, THBD, XCR1
Annotation genes
CADM1, CLEC9A, IRF8, XCR1
Annotation rationales
XCR1 and CLEC9A (DNGR1) define necrotic-antigen sensing and trafficking to MHC-I, while IRF8 underpins lineage identity and cross-presentation machinery. CADM1 supports stable contacts with T cells; low-level DNASE1L3/IDO1 suggests tonic self-antigen handling and peripheral tolerance.
Functional implications
Maintains constant sampling of apoptotic material and prepares antigen for CD8⁺ priming without overt inflammation. Provides the steady reservoir of cross-presenting DCs that rapidly convert to activated states upon infection or tumor antigens.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.