Cell state · L2
DC.cDC1.proliferative
110 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AURKB, BIRC5, CDCA3, CDK1, CDKN3, CENPF, CENPM, CENPW, CKS1B, HMGB2, HMGN2, MAD2L1, PCLAF, PLK1, RRM2, STMN1, TUBB, UBE2C, ZWINT
Annotation genes
BIRC5, CDK1, PLK1, UBE2C
Annotation rationales
CDK1/PLK1/UBE2C and BIRC5 indicate active G2/M cycling to replenish the cDC1 pool after attrition or inflammatory demand. Chromatin compaction (HMGB2/HMGN2) and spindle genes support robust mitosis.
Functional implications
Expands cross-presenting capacity in draining nodes and tissues during infection or cancer therapy. Ensures sustained DC availability for ongoing waves of T-cell priming and memory formation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.