Cell subtype · L1S
MAC.LAM
14,435 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
LIPA, TREM2, APOE, GPNMB, LGALS3
Annotation genes
TREM2, GPNMB, LIPA
Annotation rationales
Lipid-associated macrophages are tissue macrophages adapted to lipid-rich environments and characterized by lipid sensing, lysosomal processing and scavenging programs.
Functional implications
They clear extracellular lipids and damaged cells and can buffer metabolic stress, while chronic activation may reinforce inflammation and fibrosis.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.