Cell state · L2
MAC.LAM.lipid_opsonization
1,070 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AMDHD2, CFB, FSCN3, PINK1-AS, PNPLA6, RETN, SCO2, SLC15A3, TRIM28
Annotation genes
CFB, PNPLA6, RETN, SCO2
Annotation rationales
CFB activates alternative complement on lipid particles, PNPLA6 contributes phospholipase/esterase activity, RETN modulates adipokine signaling, SCO2 supports mitochondrial oxidation. Annotation genes indicate complement-assisted lipid handling.
Functional implications
Opsonize lipid droplets with complement (CFB), internalize and process them (PNPLA6), and couple to oxidative metabolism (SCO2) to modulate adipose inflammation and insulin responses (RETN).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.