Cell state · L2
MAC.LAM.anti_inflammatory
1,648 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ALCAM, ALDH1A2, CD82, DUSP4, IL1RN, ODC1, PHLDA1, TSPAN12
Annotation genes
ALDH1A2, DUSP4, IL1RN
Annotation rationales
IL1RN blocks IL-1 signaling; DUSP4 dampens MAPK; ALDH1A2 generates retinoic acid that promotes resolution and tissue repair in adipose. Annotation genes capture a pro-resolving LAM phenotype.
Functional implications
Resolve adipose inflammation, promote insulin sensitivity, and limit fibrosis by RA production (ALDH1A2) and cytokine braking (IL1RN/DUSP4).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.