Cell state · L2
MAC.LAM.inflammatory_APC
7,688 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
APOE, C1QA, C1QB, C1QC, CLEC10A, CPVL, CTSC, DUSP1, FCN1, FOLR2, GPNMB, HLA-DP, HLA-DQ, HLA-DR, IL1B, LTA4H, NAMPT, NR4A1, S100A8, S100A9, SELENOP, SMPDL3A
Annotation genes
APOE, GPNMB, HLA-DR, IL1B, S100A9
Annotation rationales
HLA-DR and CLEC10A indicate antigen presentation; IL1B/S100A9 reflect inflammatory activation; APOE/GPNMB/SMPDL3A couple lipid handling to immunity. Annotation genes typify lipid-associated inflammatory APCs.
Functional implications
Present lipid/oxidized antigens and amplify adipose inflammation (IL1B/S100A9), coordinating leukocyte recruitment and remodeling lipid niches (APOE/GPNMB).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.