Cell subtype · L1S
T.CD4_Th17
5,097 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
KLRB1, RORA, CCR6, IL7R, IL23R
Annotation genes
CCR6, RORA, IL23R
Annotation rationales
Th17 cells are CD4 helper T cells programmed by ROR-family transcriptional control and commonly associated with CCR6 and IL-17 pathway competence.
Functional implications
They defend mucosal barriers against extracellular bacteria and fungi, recruit neutrophils and can drive chronic inflammatory pathology when dysregulated.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.