Cell state · L2
T.CD4_Th17.cytotoxic
1,311 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CCL5, CD74, CEBPD, CMC1, CST7, CTSW, CXCR3, CXCR6, DUSP2, EFHD2, EOMES, GNLY, GYG1, GZMA, GZMH, GZMK, GZMM, HCST, HLA-DPA1, HLA-DPB1, HLA-DRB1, ID2, IFNGR1, KLRG1, MAP3K8, MATK, MYBL1, NKG7, PARP8, PLEK, PRF1, PVRIG, RFLNA, S1PR5, SAMD3, SLAMF7, SPON2, TBX21, ZNF664
Annotation genes
CXCR3, EOMES, GZMA, GZMK, NKG7, PRF1
Annotation rationales
EOMES with TBX21 (in markers) pushes Th1-like polarization; PRF1/NKG7 and multiple granzymes add lytic machinery; CXCR3/CXCR6 drive tissue positioning in inflamed sites; DUSP2 tempers MAPK. The sextet (CXCR3, EOMES, GZMA, GZMK, NKG7, PRF1) captures cytotoxic Th17 plasticity.
Functional implications
Potent pro-inflammatory Th17 that combines IL-17/IL-22 with direct killing—effective against intracellular pathogens but capable of tissue damage in chronic autoimmunity (IBD, psoriasis, MS).
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.