Cell subtype · L1S
FIB.hepatic_stellate_cell
377 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
RGS5, COL1A1, DES, LRAT, RBP1
Annotation genes
LRAT, RBP1, COL1A1
Annotation rationales
Hepatic stellate cells are perisinusoidal liver mesenchymal cells that store retinoids when quiescent and become matrix-producing myofibroblasts after injury.
Functional implications
They support sinusoidal architecture and hepatocyte signaling, but sustained activation is a major driver of liver fibrosis.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.