Cell state · L2
FIB.hepatic_stellate_cell.inflammatory
101 cells in the full atlas (not the displayed sample).
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Marker genes
ADAMTS4, ARID5B, ATP13A3, BAZ1A, CCNL1, DDX21, EMP1, HNRNPU, IRF1, KDM6B, LINC-PINT, MAN2A1, MCL1, NAMPT, NFKBIA, PLK3, PTPN1, RDH10, RGS16, SOD2
Annotation genes
ADAMTS4, IRF1, NAMPT, NFKBIA, SOD2
Annotation rationales
Stellate cells sense Kupffer-cell cytokines and hepatocyte DAMPs. IRF1 primes interferon signaling; NFKBIA establishes a brake to avoid runaway NF-κB; NAMPT boosts NAD for immunometabolic crosstalk; SOD2 protects mitochondria; ADAMTS4 opens ECM channels for leukocyte access.
Functional implications
Coordinates leukocyte ingress and inflammatory tone while protecting its own bioenergetics. Biases tissue toward resolution and controlled remodeling rather than unchecked scarring.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.