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Association counts use unique genes with 01-High Priority evidence and unique cells in the authored Specific tier (not the IC-score significance threshold). Reverse counts list meta traits and individual traits separately; these are overlapping levels of evidence, not independent totals. Counts cover the full available catalogue, not the displayed rows or sampled UMAP. Unavailable profiles are excluded from reverse counts; a dash means unavailable or an ambiguous identity, not zero. The browser initially shows 50 rows; choose Rows to change this. Complete rows remain in the HTML, and ordinary page links expose any continuation pages for AI readers and crawlers.

MAC.MDM.complement_resolving: Gene expression — page 11

How association tiers are defined — cell–trait and gene–trait

SCREATE tier definitions supplied by the atlas curator. This methods note explains the prepared classifications; it does not recompute or change any report scores or tiers.

Cell–trait tiers

Cell–trait links
Identify cell types whose regulatory activity is associated with a trait’s genetic signal.
Required for Specific or Relevant
The ICE-CREAM score derived from the mean metacell Z score must be ≥ 5.39, with BOTH nominal and adjusted ICE-CREAM P values ≤ 0.05.
Specific (Tier 1)
Also meets all cell-set enrichment analysis (CSEA) criteria in at least one tested comparison: nominal P ≤ 0.05 AND adjusted P ≤ 0.05 AND normalized enrichment score (NES) ≥ 1, all in that comparison. This indicates that trait-associated activity is concentrated in this cell type relative to the tested background.
Relevant (Tier 2)
Meets the ICE-CREAM requirements but not the additional CSEA criteria. The cell type may share trait-associated activity with other cell types.
Interpretation and report values
CSEA is cell-set enrichment analysis, analogous to gene-set enrichment analysis but using sets of cells along a ranked list of ICE-CREAM scores. The eligibility score derived from the mean metacell Z score is not the displayed mean IC score. Do not infer a tier from the displayed mean, its descriptive Significance column, or a single CSEA summary value. Reports preserve prepared tiers; Other means an available association outside Specific/Relevant, and unavailable is not zero or proof of biological irrelevance.
Meta traits and individual traits
Use the prepared tier for the exact meta trait or individual trait. A meta trait’s Best child CSEA FDR is the lowest available child FDR, not a combined or meta-trait significance test. Its displayed mean child NES is descriptive, not a new CSEA test. These summaries must not be used to reconstruct or override the meta-trait tier.

Gene–trait priorities (variant–tCRE–gene evidence)

Variant–tCRE–gene links
Candidate variants connect to genes through overlapping promoters or distal transcribed cis-regulatory elements (tCREs) linked to gene promoters by the Activity-by-Contact (ABC) model.
Required genetic support
The variant belongs to a purity-passing SuSiE credible set OR qualifies for Borzoi rescue. Borzoi rescue requires BOTH a variant-causality score ≥ 0.3 AND linkage disequilibrium with the lead variant of r² ≥ 0.2.
Required cellular support
The overlapping promoter has positive tCRE activity OR the distal element has a passing cell-specific ABC link to the gene, in a Specific or Relevant cell subtype (L1S) or fine-grained state (L2). BOTH genetic and cellular support are required for High or Medium priority.
High priority
Among records meeting both minimum requirements, High requires a genetic score ≥ 0.5 AND a Layer 1 correlation > 0.3 between tCRE activity and the trait’s cellular profile across cell subtypes.
Medium priority
Meets both minimum requirements but not one or both additional High thresholds. The genetic score is the higher of the SuSiE posterior inclusion probability (PIP) and the Borzoi variant-causality score.
Same-record evidence and aggregation
Each priority requires genetic and cellular evidence supporting the SAME variant–tCRE–gene record. Do not combine thresholds or evidence from different records to create a qualifying link. A gene receives the highest priority observed among its supporting records. A tCRE summary uses supporting records for that exact tCRE, not every trait of its linked genes. Separately displayed aggregate scores do not relax the same-record rule.
Limits of interpretation
A priority is candidate-association evidence, not proof of a causal variant, causal gene, causal cell type or treatment efficacy. Missing evidence is unavailable, not zero. MAGMA −log10(P), displayed credibility scores, cellular-context scores and G/C tier codes must not be substituted for these eligibility tests; use the provided records and their documented fields.

State · 1,931 full-atlas cells · all tissues.

Marker genes and cell annotation · Open this population in Cell Browser →

Mean expression uses the current overview’s precomputed gene means from the displayed 10,000-cell sample, matching the overview gene-ranking panel. These are not full-population means and are not IC scores. Every gene with a finite value is included, including zero expression.

Rows 10,001–11,000 of 28,231; ranked by score descending. Equal values use name/identifier order.

Gene expression ranked for MAC.MDM.complement_resolving
Browsers#GeneMean expressionMeta traits (High Priority)Individual traits (High Priority)
10001AC125421.20.00——
10002AC125494.20.00——
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10115AC133106.10.00——
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10299AC211486.50.00——
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10301AC215522.30.00——
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10311AC233976.10.00——
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10325AC239804.10.00——
10326AC239809.30.00——
10327AC240274.10.00——
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10331AC243547.30.00——
10332AC243562.30.00——
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10361AC244517.110.00——
10362AC244517.120.00——
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10366AC244517.90.00——
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10368AC245014.10.00——
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10375AC245052.70.00——
10376AC245060.20.00——
10377AC245060.50.00——
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10379AC245100.10.00——
10380AC245123.10.00——
10381AC245140.10.00——
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10386AC245297.20.00——
10387AC245297.30.00——
10388AC245427.10.00——
10389AC245519.10.00——
10390AC245748.10.00——
10391AC245884.10.00——
10392AC245884.100.00——
10393AC245884.80.00——
10394AC246680.10.00——
10395AC246785.30.00——
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10397AC246817.20.00——
10398AC247036.10.00——
10399AC253536.60.00——
10400AC254562.20.00——
10401AC254562.30.00——
10402AC254629.10.00——
10403AC254633.10.00——
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10415ACBD40.001439
10416ACBD50.0011
10417ACBD70.0000
10418ACCSL0.0013
10419ACD0.002063
10420ACE0.001144
10421ACE20.00——
10422ACER10.0000
10423ACER20.0021
10424ACER30.0046
10425ACHE0.002283
10426ACKR10.002035
10427ACKR20.0000
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10436ACOT40.0002
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10438ACOT70.007165
10439ACOX20.001216
10440ACOXL0.001036
10441ACP40.0000
10442ACP60.00——
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10444ACPP0.00——
10445ACR0.00——
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10450ACSL60.0052
10451ACSM10.00924
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10455ACSM40.00——
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10457ACSS10.00——
10458ACSS20.0033218
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10460ACTA10.0016
10461ACTA20.0055
10462ACTA2-AS10.00——
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10464ACTC10.0000
10465ACTG20.0000
10466ACTL100.0044
10467ACTL6A0.0000
10468ACTL6B0.001128
10469ACTL7B0.00——
10470ACTL80.0000
10471ACTN1-AS10.00——
10472ACTN20.0025
10473ACTN30.0034
10474ACTR1B0.00——
10475ACTR3B0.0011
10476ACTR3C0.002030
10477ACTR60.0005
10478ACTR80.0011
10479ACTRT10.00——
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10492AD000671.20.00——
10493AD000671.30.00——
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10496ADAD20.0011
10497ADAL0.00——
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10501ADAM190.001436
10502ADAM200.0000
10503ADAM210.0000
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10507ADAM300.00——
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10510ADAM70.0000
10511ADAMDEC10.0022
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10526ADAMTS40.001524
10527ADAMTS50.001223
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10529ADAMTS70.0050108
10530ADAMTS80.001017
10531ADAMTS90.0078
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10533ADAMTS9-AS20.0066
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10535ADAMTSL20.003142
10536ADAMTSL30.00516
10537ADAMTSL40.0091187
10538ADAMTSL50.0012
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10540ADARB20.0033
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10542ADAT10.0000
10543ADAT20.0032
10544ADCK10.0000
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10546ADCK50.0038
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10548ADCY100.0010
10549ADCY20.0000
10550ADCY30.002566
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10553ADCY60.0000
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10555ADCYAP10.0011
10556ADCYAP1R10.0012
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10564ADGRB20.0024
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10568ADGRD20.0021
10569ADGRE10.0054
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10572ADGRF20.00——
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10574ADGRF40.0025
10575ADGRF50.0024
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10577ADGRG20.00——
10578ADGRG30.0011
10579ADGRG40.00——
10580ADGRG50.0001
10581ADGRG60.0038
10582ADGRG70.001212
10583ADGRL10.001058
10584ADGRL20.0035
10585ADGRL30.0000
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