Cell state · L2
MAC.MDM.complement_resolving
1,931 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
C1QA, C1QC, CD163, CD163L1, DAB2, F13A1, FOLR2, IGF1, LGMN, LILRB5, LTC4S, LYVE1, MS4A4A, PLTP, RGL1, RNASE1, SELENOP, SLCO2B1, STAB1, WWP1
Annotation genes
C1QA, C1QC, CD163, IGF1, LYVE1, RNASE1, STAB1
Annotation rationales
C1QA/C1QC drive efferocytosis; CD163/STAB1/LYVE1 mark tissue-resident pro-resolving macrophages; IGF1 supports repair; RNASE1 clears extracellular RNA that fuels thrombosis/inflammation. Annotation genes define resolution/repair MDMs.
Functional implications
Remove apoptotic cells and immune complexes, promote endothelial and epithelial healing (IGF1), clear pro-thrombotic eRNA (RNASE1), and restore homeostasis after acute inflammation.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.