Cell subtype · L1S
T.CD4_Tfh
4,668 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CXCR5, PDCD1, ICOS, BCL6, IL21
Annotation genes
CXCR5, BCL6, IL21
Annotation rationales
Follicular helper CD4 T cells are specialized lymphoid-follicle cells directed by BCL6 and CXCR5 to interact with germinal-centre B cells.
Functional implications
They provide IL-21, co-stimulation and selection signals required for antibody affinity maturation, class switching and memory formation.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.