Cell state · L2
T.CD4_Tfh.suppression_exhaustion
768 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CD38, CTLA4, ENTPD1, LAG3, LGMN, LINC01229, LINC01943, METRNL, MIR4435-2HG, PRDM1, PTMS, SH2D2A, SNX9, TNFRSF18, UCP2, ZBTB32, ZEB2
Annotation genes
CD38, CTLA4, ENTPD1, LAG3, PRDM1
Annotation rationales
CTLA4 and ENTPD1 (CD39) enforce suppressive tone; LAG3 adds checkpoint restraint; PRDM1 (Blimp-1) drives post-activation contraction; CD38 marks recent activation.
Functional implications
Constrain GC magnitude and duration—limit autoimmunity, promote contraction, and prevent Tfh over-expansion after peak responses.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.