Cell state · L2
ILC2.quiescent
201 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BZW1, CD55, CRIP1, EZR, FTH1, HNRNPU, LMNA, MYADM, PABPC1, TAGLN2
Annotation genes
CD55, CRIP1, EZR, FTH1, LMNA, PABPC1, TAGLN2
Annotation rationales
A low-activation, housekeeping-rich profile denotes resting ILC2s that persist in tissues as sentinels. CD55 (DAF) protects the cell surface from complement-mediated damage within inflamed mucosae; cytoskeletal/structural genes EZR (ezrin), TAGLN2, and LMNA maintain polarity, migration readiness, and nuclear integrity. FTH1 (ferritin heavy chain) buffers iron/ROS to preserve fitness in oxidative barriers, while PABPC1 supports translational poise for rapid cytokine induction upon stimulation. CRIP1 suggests basal zinc/metal homeostasis relevant to redox and signaling. The inclusion of these Annotation genes highlights a poised, homeostatic ILC2 state that can swiftly transition to activation without chronic effector output.
Functional implications
Sustains tissue surveillance and epithelial crosstalk under homeostasis, preserving viability (CD55) and redox balance (FTH1) while remaining ready to convert into effector cells upon IL-33/TSLP cues. Provides low-level trophic support to epithelial and neuronal partners, maintains barrier tone, and forms a rapid-response reservoir that can expand and activate to restore tissue integrity after injury or allergen exposure.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.