Cell state · L2
ILC2.migratory
176 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CHST12, CWC27, HAPLN3, IL32, ITGAM, LIME1, NLRP1, PPP1R3E, TNFRSF18
Annotation genes
CHST12, HAPLN3, IL32, ITGAM, LIME1, NLRP1, TNFRSF18
Annotation rationales
LIME1 (linker for activation of immune cells) and ITGAM (CD11b; adhesion/diapedesis) suggest an ILC2 configuration optimized for movement and tissue entry, potentially after inflammation-induced priming. Matrix-interaction genes HAPLN3 (hyaluronan link protein) and CHST12 (chondroitin sulfation) indicate navigation within remodeled ECM and lymphatic niches. Innate danger-sensing elements IL32 and NLRP1 (inflammasome sensor) imply heightened responsiveness to microbial/stress cues, while TNFRSF18 (GITR) provides a co-stimulatory axis that can augment survival and cytokine production during trafficking. These Annotation genes anchor a migratory, immune-interactive ILC2 state that couples movement with signal integration across tissues.
Functional implications
Patrols and repositions between inflamed epithelium, draining lymphatics, and vasculature to relay type-2 signals. On arrival, engages TNFRSF18 co-stimulation to boost IL-5/IL-13 output, primes eosinophil recruitment and alternative macrophage activation, and shapes ECM remodeling via HA/chondroitin interactions (HAPLN3/CHST12). IL32/NLRP1 enhance sentinel capacity, enabling ILC2s to bridge alarmin sensing with broader innate-immune networks during allergic inflammation, helminth defense, and tissue repair.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.