Cell state · L2
FIB.transitioning.secretory_procollagen
192 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
ABCA8, ADH5, COL1A2, HOMEZ, LOXL2, MAK16, PLD3, SEC23B, TCF4, TXNIP, UBXN4, XRN2
Annotation genes
ABCA8, COL1A2, LOXL2, SEC23B, TXNIP
Annotation rationales
COPII component SEC23B and high COL1A2 signal a procollagen export surge; LOXL2 crosslinks fibers; ABCA8 supplies sterols to secretory membranes; TXNIP links glucose/redox to secretory capacity.
Functional implications
Operates as a collagen-export factory that matures and crosslinks fibers, rapidly increasing tensile strength—an intermediate state en route to load-bearing tenogenic fibroblasts or scar-forming myofibroblasts.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.