Cell state · L2
FIB.transitioning.matrix_stress
296 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CLEC2A, COL18A1, COL1A1, COL3A1, COL4A2, CPE, ETS1, F13A1, GADD45G, GRAMD2B, NTM, RAB31, RGCC, RGS2, SERPINE1, SPARC, STC2, STMN1, TMEM119, TSC22D3
Annotation genes
COL18A1, COL1A1, COL3A1, GADD45G, SERPINE1, SPARC, TSC22D3
Annotation rationales
A composite ECM program (fibrillar and basement-membrane collagens) plus SPARC builds organized scaffolds; SERPINE1 restrains plasmin to stabilize nascent fibers. Stress/gcorticoid signals (TSC22D3/GADD45G/RGS2) adapt cells to inflammatory and mechanical stress during lineage shift.
Functional implications
Lays down aligned collagen tracks and BM interfaces while damping proteolysis—stiffening along tension lines without full myofibroblast conversion; provides a stable substrate for migrating epithelia and vasculature.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.