Cell state · L2
FIB.transitioning.ISG_primed_interface
306 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
APOE, BST2, BTG1, BTG2, CD74, CDKN1A, CEBPD, CXCL2, CYP7B1, IFI27, IFI30, IFI35, IFI6, IL32, ISG15, JUNB, MYC, NNMT, NR4A1, PNRC1, PSME2, SOCS3, TNFAIP6, UBD, VCAM1, ZFP36
Annotation genes
BST2, CD74, IFI27, IFI30, IFI6, ISG15, SOCS3, VCAM1, ZFP36
Annotation rationales
Fibroblasts straddling structural and immune roles display ISGs (ISG15/IFI27/IFI6/BST2), antigen handling (CD74/IFI30), and VCAM1 for lymphocyte docking, while SOCS3/ZFP36 dampen cytokine bursts. NNMT suggests metabolic rewiring during transition.
Functional implications
Operates as an antiviral, leukocyte-positioning sentinel that preserves tissue structure: presents/handles antigens, supports immune cell adhesion, yet prevents chronic activation via strong negative feedback circuits.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.