Cell state · L2
FIB.interstitial.stress_secretory
849 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AQP1, CAPG, CAV1, CRIP1, CRIP2, EMP3, PHLDA2, PRSS23, S100A16, SERPINE2, TNFRSF12A
Annotation genes
AQP1, CAV1, SERPINE2, TNFRSF12A
Annotation rationales
Fn14 (TNFRSF12A) makes fibroblasts hyper-responsive to TWEAK during injury; SERPINE2 balances protease activity; CAV1 supports caveolar trafficking of receptors; AQP1 helps interstitial fluid dynamics.
Functional implications
Rapidly adjusts secretion (proteases, serpins, cytokines) and membrane receptor availability; controls edema and matrix proteolysis to protect tissue structure during acute damage.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.