Cell state · L2
FIB.interstitial.remodeling
3,944 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
C16orf89, CADM3, CLU, CRYAB, CTSK, GPNMB, IGFBP6, MMP2, NPC2, NUPR1, PCOLCE2, PLA2G2A, SFRP1, SFRP2
Annotation genes
CTSK, GPNMB, MMP2, PCOLCE2
Annotation rationales
High protease activity (MMP2/CTSK) with PCOLCE2 for collagen maturation and SFRP1/2 to tune Wnt—hallmarks of active remodeling. GPNMB supports repair and macrophage crosstalk; CRYAB/CLU protect proteins during stress.
Functional implications
Turns over aged collagen, widens interstitial pathways, and sets new fiber alignment; communicates with macrophages to coordinate debris clearance and resolution.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.