SCREATE

Cell subtype · L1S

EPI.skin_interfollicular_spinous

3,779 cells in the full atlas (not the displayed sample).

These are the cell-population annotations shown in the SCREATE Cell Browser.

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Marker genes

KRT1, KRT10, DSG1, DSP, SFN, IVL

Annotation genes

KRT1, KRT10, DSG1, SFN

Annotation rationales

Interfollicular spinous keratinocytes are suprabasal epidermal cells beginning terminal differentiation. KRT1, KRT10 and prominent desmosomal adhesion give the spinous layer its characteristic mechanical strength.

Functional implications

They reinforce the epidermis, resist shear and mature into outer barrier layers that limit water loss and environmental entry.

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Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.