Cell state · L2
EPI.skin_interfollicular_spinous.baseline
744 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CLEC2A, CLEC2B, CYP1A1, DMKN, DSC1, DSG1, GLTP, KRT1, KRT10, MYC, RORA, SOX15, THBD
Annotation genes
DMKN, DSC1, DSG1, KRT1, KRT10
Annotation rationales
High KRT1/KRT10 with desmosomal genes (DSG1/DSC1) and DMKN typify differentiated spinous layer above the basal layer. Expanded: this cohesive sheet absorbs mechanical stress and supports water/lipid transport to upper layers.
Functional implications
Form the mechanically strong, adhesive sheet of the spinous layer; provide scaffold for upward differentiation toward the granular/stratum corneum. Maintains epidermal resilience.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.