Cell subtype · L1S
EPI.alveolar_type_1
1,093 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
AGER, PDPN, CAV1, EMP2, HOPX
Annotation genes
AGER, PDPN, CAV1, HOPX
Annotation rationales
Alveolar type I cells are extremely thin squamous epithelial cells specialized to line the gas-exchange surface of lung alveoli. AGER, PDPN and caveolar genes support their flattened, barrier-forming identity.
Functional implications
They create a minimal diffusion distance for oxygen and carbon dioxide while maintaining the air–blood barrier and regulating alveolar fluid balance.
More specific populations
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.