Cell state · L2
EPI.alveolar_type_1.activated
148 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
Read trait, study and gene evidence reports for this population →
Explore this population in Cell Browser →
Marker genes
ANKRD36B, CMTR2, CSNK1G1, EXOC2, GPRC5D-AS1, LINC01473, MIR222HG, MXD1, NABP1, NEAT1, OSBPL11, OTULIN, PHC3, PIK3R3, SHROOM3, SIMC1, TNFAIP3, TSC22D2, UEVLD
Annotation genes
NEAT1, PIK3R3, SHROOM3, TNFAIP3, TSC22D2
Annotation rationales
SHROOM3 promotes actin–junction remodeling for resealing barrier gaps after injury. PIK3R3 activates PI3K-dependent survival under mechanical stretch, maintaining viability of AT1 cells in the thin gas-exchange barrier. TNFAIP3 and OTULIN edit NF-κB and ubiquitin cascades, limiting excessive inflammation. TSC22D2 and NEAT1 reflect TGF-β and stress-driven transcriptional programs that reshape the injury response while maintaining epithelial identity.
Functional implications
Reinforces and repairs the alveolar barrier after injury by reorganizing cytoskeleton, damping NF-κB activation, and sustaining survival under shear stress. Coordinates with fibroblasts and immune cells to guide tissue repair while preserving gas exchange efficiency.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.