Cell state · L2
DC.pDC.baseline
723 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CLEC4C, GZMB, IL3RA, IRF7, IRF8, SPIB, TCF4, TLR7, TLR9
Annotation genes
CLEC4C, GZMB, IL3RA, IRF7, TCF4, TLR7
Annotation rationales
CLEC4C/IL3RA/TCF4 define human pDC identity, IRF7 primes a rapid type-I IFN surge upon TLR7/9 ligation; GZMB is a characteristic resting product of human pDCs.
Functional implications
On nucleic-acid sensing, unleashes high-titer IFN-α/β to inhibit viral replication, activate NK cells, and shape Th1/B-cell responses; acts within minutes to hours of infection.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.