Cell state · L2
DC.mig.baseline
405 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BIRC3, CCL17, CCL19, CCL22, CCR7, CD274, CXCR4, DUSP1, FSCN1, IDO1, IRF4, LAMP3, LTB, MARCKSL1, NFKBIA, PDCD1LG2, RELB, S1PR1
Annotation genes
CCL19, CCR7, CD274, FSCN1, IDO1, LAMP3, PDCD1LG2
Annotation rationales
CCR7/CCL19 define LN-homing; FSCN1/LAMP3 mark mature migratory DCs; checkpoint/tryptophan catabolism (CD274/PDCD1LG2/IDO1) restrain over-priming. IRF4/RELB sustain activation needed for T-cell instruction.
Functional implications
Central “hub” APCs in LNs that present processed tissue antigens to both CD4⁺ and CD8⁺ T cells while using PD-L1/PD-L2/IDO1 to balance effector expansion with tolerance.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.