Cell state · L2
B.naive.remodeling
2,765 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
CHKB
Annotation genes
CHKB
Annotation rationales
CHKB catalyzes phosphatidylcholine synthesis; enriched CHKB points to active plasma-membrane (PM) lipid remodeling. In naïve B cells, PM composition governs BCR nanocluster organization, membrane curvature for endocytosis, and integrin function—tuning signal initiation without altering core identity.
Functional implications
A PM-remodeling naïve subset that optimizes BCR nano-organization, endocytic pit formation, and adhesion/chemotaxis. This raises the efficiency of primary antigen uptake and early synapse formation with T cells/DCs, improving the likelihood of GC initiation under subthreshold or fleeting antigen.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.