Cell state · L2
B.naive.proteostasis
1,860 cells in the full atlas (not the displayed sample).
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Marker genes
UBE2F
Annotation genes
UBE2F
Annotation rationales
UBE2F is an E2 enzyme that NEDDylates cullins, activating CRL ubiquitin ligases. Enrichment implies elevated turnover of short-lived signaling adaptors and receptors, sharpening BCR thresholding and preventing tonic-signal drift while cells remain naïve.
Functional implications
Operates as a proteostasis-tuned naïve subset that continuously edits signaling complexes via NEDDylation-dependent CRLs. This keeps BCR and co-receptor tone within a narrow window—supporting longevity, minimizing autoreactivity, and enabling crisp transitions to activation when authentic antigen appears.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.