Cell state · L2
B.naive.metabolic
2,525 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
DNPH1, EBI3, FABP5, NME1, NME2, PKM, PSME2, SRM, TXN
Annotation genes
PKM, PSME2, TXN
Annotation rationales
PKM indicates glycolytic readiness; TXN (thioredoxin) and SRM (polyamine synthesis) buffer redox and biosynthetic demands; PSME2 (PA28β) enhances proteasome peptidase activity—important for antigen processing and protein quality control. NME1/2 support nucleotide homeostasis; FABP5 channels fatty acids during activation transitions. This profile marks a bioenergetically pre-armed but immunologically naïve state.
Functional implications
Provides a redox-stabilized, ATP-ready naïve pool that can flip metabolic switches rapidly at priming, sustaining proliferation, antigen processing, and membrane expansion. Functionally, these cells improve time-to-response and survival in nutrient/ROS-fluctuating niches (e.g., inflamed LNs), increasing the probability of successful GC entry.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.