Cell state · L2
B.naive.baseline
1,209 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
BACH2, BTLA, FCER2, FCRL1, FOXO1, HVCN1, IL4R, TCL1A
Annotation genes
FCER2, FCRL1, TCL1A
Annotation rationales
TCL1A/FCER2 (CD23)/FCRL1 define canonical naïve/transitional identity; BACH2/FOXO1/BTLA enforce quiescence and raise activation thresholds; HVCN1 (proton channel) supports BCR signal tuning via NADPH oxidase coupling; IL4R poises cells for T-cell–derived survival cues. This constellation is the resting, diverse repertoire poised for first encounters.
Functional implications
Serves as the long-lived repertoire reservoir: maintains breadth and self-tolerance while remaining ready to mount primary responses. Via CD23 and complement pathways it captures opsonized antigen efficiently; upon adequate help, it can rapidly proliferate or differentiate, providing the foundation for vaccine responses and initial pathogen control.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.