Cell state · L2
B.naive.antigen_presenting_ready
2,088 cells in the full atlas (not the displayed sample).
These are the cell-population annotations shown in the SCREATE Cell Browser.
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Marker genes
SYS1
Annotation genes
SYS1
Annotation rationales
SYS1 is a Golgi/TGN trafficking factor; its enrichment implies expanded secretory/endolysosomal routing capacity. In naïve B cells, this biases internalized BCR–antigen complexes toward MHC-II compartments and optimizes surface–endosome recycling kinetics without invoking a full activation program.
Functional implications
Antigen-processing–primed naïve cells that can swiftly deliver BCR cargo to MIIC for peptide loading and re-express BCR/MHC-II efficiently. Functionally, they shorten the lag to productive Tfh engagement, improving the odds of successful priming and GC seeding during weak or transient antigen exposure.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.