Cell state · L2
B.germinal_center.LZ_selection
171 cells in the full atlas (not the displayed sample).
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Marker genes
BTNL9, CAMK1, CD74, LCK, LINC02099, MAML3, MCTP2, MS4A1, P2RY12, PEA15, PRPSAP2, PTAFR, RASL11A, SERPINA9
Annotation genes
CAMK1, CD74, LCK, MS4A1, PTAFR, SERPINA9
Annotation rationales
SERPINA9 and CD74 highlight enhanced MHC-II antigen presentation capacity. LCK and CAMK1 reflect BCR/TCR-proximal signaling during Tfh engagement. PTAFR (platelet-activating factor receptor) adds lipid-inflammatory responsiveness. This constellation defines LZ B cells under selection, interacting with Tfh cells and FDCs.
Functional implications
Executes antigen presentation and selection, presenting peptide–MHC II to Tfh cells, integrating survival/death signals, and determining lineage outcomes (plasma vs memory) based on affinity and co-stimulatory cues.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.