Cell state · L2
B.germinal_center.LZ_memory_precursor
103 cells in the full atlas (not the displayed sample).
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Marker genes
ACP5, AHNAK, ANXA4, CAPG, CD1C, CD82, FCER2, FCMR, IFITM2, IL2RG, MTSS1, S1PR1, SELL, TXNIP
Annotation genes
CD82, FCER2, FCMR, S1PR1, SELL, TXNIP
Annotation rationales
Reacquisition of recirculation/egress markers (S1PR1, SELL/CD62L) and memory-related receptors (FCER2/CD23, FCMR) indicate memory commitment. CD82 supports adhesion/synapse stability, while TXNIP signals metabolic restraint to promote longevity. Together, these define GC B cells exiting the LZ toward the memory lineage.
Functional implications
Seeds the long-lived memory B cell pool, exiting follicles and homing to lymphoid or bone marrow niches. These cells preserve antigen experience and sustain long-term humoral memory with a metabolically frugal, survival-biased program.
Marker and functional descriptions are atlas annotations. Explore gene expression, trait associations and regulatory elements in the interactive browsers; see the browser guide.